Chr07.g52792

Functional evidence

eggNOG

126957.SMAR013089-PA,L,[This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand]

Gene Ontology

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand | GO:0000003//reproduction; GO:0000075//cell cycle checkpoint; GO:0000077//DNA damage checkpoint; GO:0000082//G1/S transition of mitotic cell cycle; GO:0000083//regulation of transcription involved in G1/S transition of mitotic cell cycle; GO:0000122//negative regulation of transcription from RNA polymerase II promoter; GO:0000226//microtubule cytoskeleton organization; GO:0000278//mitotic cell cycle; GO:0000302//response to reactive oxygen species; GO:0000723//telomere maintenance; GO:0000731//DNA synthesis involved in DNA repair; GO:0001101//response to acid chemical; GO:0001889//liver development; GO:0002064//epithelial cell development; GO:0002065//columnar/cuboidal epithelial cell differentiation; GO:0002066//columnar/cuboidal epithelial cell development; GO:0002376//immune system process; GO:0003006//developmental process involved in reproduction; GO:0006139//nucleobase-containing compound metabolic process; GO:0006259//DNA metabolic process; GO:0006260//DNA replication; GO:0006261//DNA-dependent DNA replication; GO:0006271//DNA strand elongation involved in DNA replication; GO:0006272//leading strand elongation; GO:0006275//regulation of DNA replication; GO:0006277//DNA amplification; GO:0006281//DNA repair; GO:0006282//regulation of DNA repair; GO:0006283//transcription-coupled nucleotide-excision repair; GO:0006284//base-excision repair; GO:0006287//base-excision repair, gap-filling; GO:0006289//nucleotide-excision repair; GO:0006296//nucleotide-excision repair, DNA incision, 5'-to lesion; GO:0006297//nucleotide-excision repair, DNA gap filling; GO:0006298//mismatch repair; GO:0006301//postreplication repair; GO:0006355//regulation of transcription, DNA-templated; GO:0006357//regulation of transcription from RNA polymerase II promoter; GO:0006464//cellular protein modification process; GO:0006725//cellular aromatic compound metabolic process; GO:0006807//nitrogen compound metabolic process; GO:0006950//response to stress; GO:0006955//immune response; GO:0006959//humoral immune response; GO:0006974//cellular response to DNA damage stimulus; GO:0006977//DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; GO:0006979//response to oxidative stress; GO:0006996//organelle organization; GO:0007010//cytoskeleton organization; GO:0007017//microtubule-based process; GO:0007049//cell cycle; GO:0007051//spindle organization; GO:0007052//mitotic spindle organization; GO:0007093//mitotic cell cycle checkpoint; GO:0007154//cell communication; GO:0007165//signal transduction; GO:0007275//multicellular organism development; GO:0007276//gamete generation; GO:0007281//germ cell development; GO:0007292//female gamete generation; GO:0007304//chorion-containing eggshell formation; GO:0007306//eggshell chorion assembly; GO:0007307//eggshell chorion gene amplification; GO:0007346//regulation of mitotic cell cycle; GO:0007507//heart development; GO:0007584//response to nutrient; GO:0008150//biological_process; GO:0008152//metabolic process; GO:0008283//cell proliferation; GO:0009058//biosynthetic process; GO:0009059//macromolecule biosynthetic process; GO:0009314//response to radiation; GO:0009410//response to xenobiotic stimulus; GO:0009411//response to UV; GO:0009416//response to light stimulus; GO:0009605//response to external stimulus; GO:0009607//response to biotic stimulus; GO:0009617//response to bacterium; GO:0009628//response to abiotic stimulus; GO:0009636//response to toxic substance; GO:0009653//anatomical structure morphogenesis; GO:0009719//response to endogenous stimulus; GO:0009725//response to hormone; GO:0009888//tissue development; GO:0009889//regulation of biosynthetic process; GO:0009890//negative regulation of biosynthetic process; GO:0009891//positive regulation of biosynthetic process; GO:0009892//negative regulation of metabolic process; GO:0009893//positive regulation of metabolic process; GO:0009987//cellular process; GO:0009991//response to extracellular stimulus; GO:0010033//response to organic substance; GO:0010035//response to inorganic substance; GO:0010038//response to metal ion; GO:0010243//response to organonitrogen compound; GO:0010468//regulation of gene expression; GO:0010556//regulation of macromolecule biosynthetic process; GO:0010557//positive regulation of macromolecule biosynthetic process; GO:0010558//negative regulation of macromolecule biosynthetic process; GO:0010564//regulation of cell cycle process; GO:0010604//positive regulation of macromolecule metabolic process; GO:0010605//negative regulation of macromolecule metabolic process; GO:0010629//negative regulation of gene expression; GO:0010927//cellular component assembly involved in morphogenesis; GO:0010948//negative regulation of cell cycle process; GO:0014070//response to organic cyclic compound; GO:0014823//response to activity; GO:0016043//cellular component organization; GO:0016070//RNA metabolic process; GO:0016567//protein ubiquitination; GO:0018130//heterocycle biosynthetic process; GO:0019219//regulation of nucleobase-containing compound metabolic process; GO:0019222//regulation of metabolic process; GO:0019438//aromatic compound biosynthetic process; GO:0019538//protein metabolic process; GO:0019725//cellular homeostasis; GO:0019730//antimicrobial humoral response; GO:0019953//sexual reproduction; GO:0019985//translesion synthesis; GO:0022402//cell cycle process; GO:0022412//cellular process involved in reproduction in multicellular organism; GO:0022414//reproductive process; GO:0022607//cellular component assembly; GO:0022616//DNA strand elongation; GO:0023052//signaling; GO:0030154//cell differentiation; GO:0030330//DNA damage response, signal transduction by p53 class mediator; GO:0030703//eggshell formation; GO:0030707//ovarian follicle cell development; GO:0030855//epithelial cell differentiation; GO:0031099//regeneration; GO:0031100//animal organ regeneration; GO:0031297//replication fork processing; GO:0031323//regulation of cellular metabolic process; GO:0031324//negative regulation of cellular metabolic process; GO:0031325//positive regulation of cellular metabolic process; GO:0031326//regulation of cellular biosynthetic process; GO:0031327//negative regulation of cellular biosynthetic process; GO:0031328//positive regulation of cellular biosynthetic process; GO:0031570//DNA integrity checkpoint; GO:0031571//mitotic G1 DNA damage checkpoint; GO:0031667//response to nutrient levels; GO:0031960//response to corticosteroid; GO:0032069//regulation of nuclease activity; GO:0032070//regulation of deoxyribonuclease activity; GO:0032075//positive regulation of nuclease activity; GO:0032077//positive regulation of deoxyribonuclease activity; GO:0032200//telomere organization; GO:0032201//telomere maintenance via semi-conservative replication; GO:0032355//response to estradiol; GO:0032446//protein modification by small protein conjugation; GO:0032501//multicellular organismal process; GO:0032502//developmental process; GO:0032504//multicellular organism reproduction; GO:0032989//cellular component morphogenesis; GO:0033260//nuclear DNA replication; GO:0033554//cellular response to stress; GO:0033683//nucleotide-excision repair, DNA incision; GO:0033993//response to lipid; GO:0034599//cellular response to oxidative stress; GO:0034614//cellular response to reactive oxygen species; GO:0034641//cellular nitrogen compound metabolic process; GO:0034644//cellular response to UV; GO:0034645//cellular macromolecule biosynthetic process; GO:0034654//nucleobase-containing compound biosynthetic process; GO:0035556//intracellular signal transduction; GO:0035690//cellular response to drug; GO:0036211//protein modification process; GO:0042221//response to chemical; GO:0042276//error-prone translesion synthesis; GO:0042493//response to drug; GO:0042542//response to hydrogen peroxide; GO:0042592//homeostatic process; GO:0042698//ovulation cycle; GO:0042769//DNA damage response, detection of DNA damage; GO:0042770//signal transduction in response to DNA damage; GO:0043085//positive regulation of catalytic activity; GO:0043170//macromolecule metabolic process; GO:0043200//response to amino acid; GO:0043207//response to external biotic stimulus; GO:0043412//macromolecule modification; GO:0043933//macromolecular complex subunit organization; GO:0044085//cellular component biogenesis; GO:0044093//positive regulation of molecular function; GO:0044237//cellular metabolic process; GO:0044238//primary metabolic process; GO:0044249//cellular biosynthetic process; GO:0044260//cellular macromolecule metabolic process; GO:0044267//cellular protein metabolic process; GO:0044271//cellular nitrogen compound biosynthetic process; GO:0044703//multi-organism reproductive process; GO:0044770//cell cycle phase transition; GO:0044772//mitotic cell cycle phase transition; GO:0044773//mitotic DNA damage checkpoint; GO:0044774//mitotic DNA integrity checkpoint; GO:0044783//G1 DNA damage checkpoint; GO:0044786//cell cycle DNA replication; GO:0044819//mitotic G1/S transition checkpoint; GO:0044843//cell cycle G1/S phase transition; GO:0044849//estrous cycle; GO:0045005//DNA-dependent DNA replication maintenance of fidelity; GO:0045739//positive regulation of DNA repair; GO:0045740//positive regulation of DNA replication; GO:0045786//negative regulation of cell cycle; GO:0045787//positive regulation of cell cycle; GO:0045892//negative regulation of transcription, DNA-templated; GO:0045930//negative regulation of mitotic cell cycle; GO:0045934//negative regulation of nucleobase-containing compound metabolic process; GO:0045935//positive regulation of nucleobase-containing compound metabolic process; GO:0046483//heterocycle metabolic process; GO:0046677//response to antibiotic; GO:0046686//response to cadmium ion; GO:0048468//cell development; GO:0048477//oogenesis; GO:0048511//rhythmic process; GO:0048513//animal organ development; GO:0048518//positive regulation of biological process; GO:0048519//negative regulation of biological process; GO:0048522//positive regulation of cellular process; GO:0048523//negative regulation of cellular process; GO:0048545//response to steroid hormone; GO:0048583//regulation of response to stimulus; GO:0048584//positive regulation of response to stimulus; GO:0048609//multicellular organismal reproductive process; GO:0048646//anatomical structure formation involved in morphogenesis; GO:0048731//system development; GO:0048732//gland development; GO:0048856//anatomical structure development; GO:0048869//cellular developmental process; GO:0050789//regulation of biological process; GO:0050790//regulation of catalytic activity; GO:0050794//regulation of cellular process; GO:0050896//response to stimulus; GO:0051052//regulation of DNA metabolic process; GO:0051054//positive regulation of DNA metabolic process; GO:0051171//regulation of nitrogen compound metabolic process; GO:0051172//negative regulation of nitrogen compound metabolic process; GO:0051173//positive regulation of nitrogen compound metabolic process; GO:0051252//regulation of RNA metabolic process; GO:0051253//negative regulation of RNA metabolic process; GO:0051259//protein oligomerization; GO:0051260//protein homooligomerization; GO:0051276//chromosome organization; GO:0051336//regulation of hydrolase activity; GO:0051345//positive regulation of hydrolase activity; GO:0051384//response to glucocorticoid; GO:0051606//detection of stimulus; GO:0051704//multi-organism process; GO:0051707//response to other organism; GO:0051716//cellular response to stimulus; GO:0051726//regulation of cell cycle; GO:0060249//anatomical structure homeostasis; GO:0060255//regulation of macromolecule metabolic process; GO:0060429//epithelium development; GO:0061008//hepaticobiliary system development; GO:0065003//macromolecular complex assembly; GO:0065007//biological regulation; GO:0065008//regulation of biological quality; GO:0065009//regulation of molecular function; GO:0070206//protein trimerization; GO:0070207//protein homotrimerization; GO:0070301//cellular response to hydrogen peroxide; GO:0070647//protein modification by small protein conjugation or removal; GO:0070887//cellular response to chemical stimulus; GO:0070987//error-free translesion synthesis; GO:0071156//regulation of cell cycle arrest; GO:0071158//positive regulation of cell cycle arrest; GO:0071214//cellular response to abiotic stimulus; GO:0071236//cellular response to antibiotic; GO:0071466//cellular response to xenobiotic stimulus; GO:0071478//cellular response to radiation; GO:0071482//cellular response to light stimulus; GO:0071548//response to dexamethasone; GO:0071704//organic substance metabolic process; GO:0071840//cellular component organization or biogenesis; GO:0071897//DNA biosynthetic process; GO:0072331//signal transduction by p53 class mediator; GO:0072359//circulatory system development; GO:0072395//signal transduction involved in cell cycle checkpoint; GO:0072401//signal transduction involved in DNA integrity checkpoint; GO:0072413//signal transduction involved in mitotic cell cycle checkpoint; GO:0072422//signal transduction involved in DNA damage checkpoint; GO:0072431//signal transduction involved in mitotic G1 DNA damage checkpoint; GO:0080090//regulation of primary metabolic process; GO:0080134//regulation of response to stress; GO:0080135//regulation of cellular response to stress; GO:0090068//positive regulation of cell cycle process; GO:0090304//nucleic acid metabolic process; GO:0090305//nucleic acid phosphodiester bond hydrolysis; GO:0097237//cellular response to toxic substance; GO:0097327//response to antineoplastic agent; GO:0097421//liver regeneration; GO:1901360//organic cyclic compound metabolic process; GO:1901362//organic cyclic compound biosynthetic process; GO:1901564//organonitrogen compound metabolic process; GO:1901576//organic substance biosynthetic process; GO:1901654//response to ketone; GO:1901698//response to nitrogen compound; GO:1901700//response to oxygen-containing compound; GO:1901701//cellular response to oxygen-containing compound; GO:1901987//regulation of cell cycle phase transition; GO:1901988//negative regulation of cell cycle phase transition; GO:1901990//regulation of mitotic cell cycle phase transition; GO:1901991//negative regulation of mitotic cell cycle phase transition; GO:1902065//response to L-glutamate; GO:1902400//intracellular signal transduction involved in G1 DNA damage checkpoint; GO:1902402//signal transduction involved in mitotic DNA damage checkpoint; GO:1902403//signal transduction involved in mitotic DNA integrity checkpoint; GO:1902679//negative regulation of RNA biosynthetic process; GO:1902806//regulation of cell cycle G1/S phase transition; GO:1902807//negative regulation of cell cycle G1/S phase transition; GO:1902850//microtubule cytoskeleton organization involved in mitosis; GO:1902990//mitotic telomere maintenance via semi-conservative replication; GO:1903047//mitotic cell cycle process; GO:1903506//regulation of nucleic acid-templated transcription; GO:1903507//negative regulation of nucleic acid-templated transcription; GO:2000045//regulation of G1/S transition of mitotic cell cycle; GO:2000112//regulation of cellular macromolecule biosynthetic process; GO:2000113//negative regulation of cellular macromolecule biosynthetic process; GO:2000134//negative regulation of G1/S transition of mitotic cell cycle; GO:2001020//regulation of response to DNA damage stimulus; GO:2001022//positive regulation of response to DNA damage stimulus; GO:2001141//regulation of RNA biosynthetic process | GO:0000228//nuclear chromosome; GO:0000307//cyclin-dependent protein kinase holoenzyme complex; GO:0005575//cellular_component; GO:0005622//intracellular; GO:0005623//cell; GO:0005634//nucleus; GO:0005652//nuclear lamina; GO:0005654//nucleoplasm; GO:0005657//replication fork; GO:0005663//DNA replication factor C complex; GO:0005694//chromosome; GO:0005813//centrosome; GO:0005815//microtubule organizing center; GO:0005856//cytoskeleton; GO:0015630//microtubule cytoskeleton; GO:0016604//nuclear body; GO:0030894//replisome; GO:0031974//membrane-enclosed lumen; GO:0031981//nuclear lumen; GO:0032991//macromolecular complex; GO:0032993//protein-DNA complex; GO:0034399//nuclear periphery; GO:0043226//organelle; GO:0043227//membrane-bounded organelle; GO:0043228//non-membrane-bounded organelle; GO:0043229//intracellular organelle; GO:0043231//intracellular membrane-bounded organelle; GO:0043232//intracellular non-membrane-bounded organelle; GO:0043233//organelle lumen; GO:0043596//nuclear replication fork; GO:0043626//PCNA complex; GO:0044422//organelle part; GO:0044424//intracellular part; GO:0044427//chromosomal part; GO:0044428//nuclear part; GO:0044430//cytoskeletal part; GO:0044446//intracellular organelle part; GO:0044451//nucleoplasm part; GO:0044454//nuclear chromosome part; GO:0044464//cell part; GO:0044796//DNA polymerase processivity factor complex; GO:0061695//transferase complex, transferring phosphorus-containing groups; GO:0070013//intracellular organelle lumen; GO:0070557//PCNA-p21 complex; GO:1902494//catalytic complex; GO:1902554//serine/threonine protein kinase complex; GO:1902911//protein kinase complex; GO:1990234//transferase complex | GO:0000700//mismatch base pair DNA N-glycosylase activity; GO:0000701//purine-specific mismatch base pair DNA N-glycosylase activity; GO:0003674//molecular_function; GO:0003676//nucleic acid binding; GO:0003677//DNA binding; GO:0003682//chromatin binding; GO:0003684//damaged DNA binding; GO:0003690//double-stranded DNA binding; GO:0003824//catalytic activity; GO:0005102//receptor binding; GO:0005488//binding; GO:0005515//protein binding; GO:0008134//transcription factor binding; GO:0016787//hydrolase activity; GO:0016798//hydrolase activity, acting on glycosyl bonds; GO:0016799//hydrolase activity, hydrolyzing N-glycosyl compounds; GO:0019104//DNA N-glycosylase activity; GO:0019899//enzyme binding; GO:0019900//kinase binding; GO:0019901//protein kinase binding; GO:0030234//enzyme regulator activity; GO:0030331//estrogen receptor binding; GO:0030337//DNA polymerase processivity factor activity; GO:0030971//receptor tyrosine kinase binding; GO:0030983//mismatched DNA binding; GO:0032135//DNA insertion or deletion binding; GO:0032139//dinucleotide insertion or deletion binding; GO:0032404//mismatch repair complex binding; GO:0032405//MutLalpha complex binding; GO:0035035//histone acetyltransferase binding; GO:0035257//nuclear hormone receptor binding; GO:0035258//steroid hormone receptor binding; GO:0042802//identical protein binding; GO:0044877//macromolecular complex binding; GO:0051427//hormone receptor binding; GO:0070182//DNA polymerase binding; GO:0097159//organic cyclic compound binding; GO:0098772//molecular function regulator; GO:1901363//heterocyclic compound binding; GO:1990782//protein tyrosine kinase binding

KEGG

K04802 | PCNA

NR

RWR91910.1 proliferating cell nuclear antigen [Cinnamomum micranthum f. kanehirae]

Swiss-Prot

O16852.1 RecName: Full=Proliferating cell nuclear antigen; Short=PCNA; AltName: Full=Cyclin [Sarcophaga crassipalpis]